〔Abstract〕 Objective By comparing the digital detection and manual measurement of the same burn wound area in rats, the accuracy of the digital detection method for the measurement of wound area is tested, in order to obtain a simple and accurate measurement method of burn area. Methods According to the requirements of scald model, scald wounds were formed in rats. After the scald wounds were stable, digital images were taken and the wound area was calculated and included in the digital measurement group. The wound was rubbed with thin film, and the area of the wound was measured manually by calculus method and included in the manual measurement group. The vernier caliper was used to measure the inner diameter of the round mold and is included in the mold measurement group. Scald wound integrity and injury were identified, and the three groups of measurement results were compared and analyzed. Results According to the method of making rat scald model, a total of 30 complete scald wounds were obtained and pictures were taken. According to pathological biopsy, 9 cases of shallow II degree scald wounds, 9 cases of deep II degree scald wounds and 12 cases of III degree scald wounds were obtained.The scald wound area of the mold measurement group was larger than that of the manual measurement group and the digital measurement group, and the difference was statistically significant (P < 0.05). There was no statistically significant difference between the manual measurement group and the digital measurement group (P > 0.05). Pearson analysis showed that there was a very significant positive correlation between the scald wound area in the manual measurement group and the digital measurement group (r = 0.964, P < 0.01). Conclusion The digital measurement group and the manual measurement group are smaller than the mold area. There is no obvious difference between digital measurement and manual measurement and they are very similar. Digital measurement is more convenient and rapid than manual measurement, which is conducive to providing convenient and reliable reference for clinical fluid resuscitation in the early stage of scald.