〔Abstract〕 Objective To study the clinical efficacy of carboprost tromethamine combined with oxytocin in the treatment of postpartum hemorrhage. Methods A total of 100 cases of postpartum hemorrhage in Xuchang Central Hospital from May 2020 to May 2022 were randomly divided into an observation group and a control group, with 50 cases in each group. The control group was treated with oxytocin alone, and the observation group was treated with oxytocin combined with carboprost tromethamine. The therapeutic effects of the two groups were compared. Results The amount of bleeding at 2 h and 24 h after delivery in the observation group was less than that in the control group, and the difference was statistically significant (P < 0.05). The hematocrit value, hemoglobin and platelet aggregation rate of the observation group 24 hours after delivery were higher than those of the control group, and the differences were statistically significant (P < 0.05). The prothrombin time (PT), activated partial thromboplastin time (APTT) and fibrinogen (FIB) of puerpera in the observation group 24 hours after delivery were less than those in the control group, and thrombin time (TT) was longer than that in the control group, and the differences were statistically significant (P < 0.05). The heart rate of puerpera 24 hours after delivery in the observation group was lower than that in the control group, and the diastolic blood pressure and systolic blood pressure were higher than those in the control group, and the differences were statistically significant (P < 0.05). The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P < 0.05). Conclusion Oxytocin combined with carboprost tromethamine is safe and effective in the treatment of postpartum hemorrhage, which can promote the platelet aggregation rate, coagulation function and hemodynamic indexes.