〔Abstract〕 Objective To observe the clinical indexes of laparoscopic combined colonoscopy for the enucleation of large basal colon polyps in children. Methods A total of 58 children with large basal colic polyps who received surgical treatment in Children's Hospital Affiliated to Zhengzhou University from January 2017 to June 2022 were selected and divided into single-lens group and double-lens group according to random number table method, with 29 cases in each group. All the children in the two groups underwent resection of colon polyps. The children in the single endoscopic group underwent laparoscopic single endoscopic surgery, and the children in the double endoscopic group underwent laparoscopic combined with colonoscopy double endoscopic surgery. The clinical indexes and postoperative complication rate of the two groups were compared. Results The time of polyp removal, surgery time, intraoperative blood loss and total hospital stay in the two-lens group were all less than those in the single-lens group, and the differences were statistically significant (P < 0.05). The recovery time of gastrointestinal function in the two-lens group was shorter than that in the single-lens group, and the difference was statistically significant (P < 0.05). The visual analog scale (VAS) scores in the two-lens group were lower than those in the single-lens group 24 h, 48 h and 72 h after surgery, and the differences were statistically significant (P < 0.05). The serum levels of vascular endothelial growth factor (VEGF) and thromboxane B2 (TXB2) in the double-lens group were lower than those in the single-lens group 3 days after surgery, and the differences were statistically significant (P < 0.05). The incidence of postoperative complications in the two-lens group was lower than that in the single-lens group, and the difference was statistically significant (P < 0.05). Conclusion Laparoscopic combined with colonoscopy for the enucleation of large basal colon polyps in children can more accurately remove polyp tissue, reduce intraoperative blood loss, improve various postoperative clinical indicators of children, and thus promote postoperative recovery of children.