〔Abstract〕 Objective To analyze the clinical effect of Gegen Mahuang decoction in the treatment of influenza with pulmonary syndrome caused by toxic pathogens. Methods According to the 1:1 principle and random number table method, 100 cases of influenza caused by wind-cold and dampdamp-related virus admitted to Huyang Central Health Center of Yongchun County from February 2022 to July 2022 were divided into two groups, with 50 cases each. The Western medicine group was given conventional Western medicine treatment, on the basis of which the Chinese medicine group was given pueraria ephedra decoction plus or minus. The clinical efficacy, symptom improvement, inflammatory indicators, immune function and adverse reactions were compared between the two groups. Results The total effective rate of the TCM group was 96.00 %, higher than that of the Western group (84.00 %), and the difference was statistically significant (P < 0.05).The disappearance time of cough, sore throat, nasal congestion and runny nose in TCM group was significantly shorter than that in Western group, the difference was statistically significant (P < 0.05). There was no statistical significance in the time of fever reduction between the two groups (P > 0.05).After treatment, the serum levels of interleukin-6 (IL-6), IL-17, and hypersensitive C-reactive protein (hs-CRP) in the two groups were decreased to varying degrees, and the serum levels of IL-6, IL-17, hs-CRP in the Chinese medicine group were lower than those in the Western medicine group after treatment, the difference was statistically significant (P < 0.05).After treatment, the CD3+ , CD4+ , CD4+ /CD8+ of the two groups were improved to varying degrees, and after treatment, the CD3+ , CD4+ , CD4+ /CD8+ of the Chinese medicine group were higher than those of the Western medicine group, the difference was statistically significant (P < 0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P > 0.05). Conclusion The modified and modified treatment of Pueraria Mahuang decoction can effectively improve the immune function, inhibit the inflammatory response and reduce clinical symptoms in the patients with influenza with pulmonary syndrome caused by toxic pathogens. The efficacy is accurate and has certain safety.