〔Abstract〕 Objective To investigate the effect of different subtypes of human papillomavirus (HPV) on postpartum hemorrhage and neonatal outcomes. Methods A total of 230 HPV-infected parturients who delivered in the 73rd Military Hospital of the Army from January 2020 to December 2021 were selected. All the patients were divided into ordinary group (136 cases) and high-risk group (94 cases) according to prenatal HPV typing. The pregnancy outcomes, postpartum conditions, neonatal outcomes and HPV infection were compared between the two groups. Results The incidences of spontaneous abortion, premature delivery, premature rupture of membranes, and fetal intrauterine growth restriction in the high-risk group were higher than those in the ordinary group, and the incidences of postpartum hemorrhage and puerperium infection were higher than those in the ordinary group. The positive rates of HPV in amniotic fluid, umbilical cord blood, placenta, and fetal pharyngeal secretions, and the neonatal HPV infection rate were higher than those in the ordinary group, and the differences were statistically significant (P < 0.05). There was no significant difference in the incidence of fetal distress, neonatal respiratory distress, and neonatal jaundice between the two groups (P > 0.05). Conclusion High-risk subtypes of HPV can increase the incidence of postpartum hemorrhage and puerperium infection, and the risk of vertical transmission between mother and child is higher, but there is no significant effect on adverse neonatal outcomes.