〔Abstract〕 Objective To compare the efficacy and economy of three treatment methods for non-lactation mastitis. Methods A total of 120 non-lactating mastitis patients diagnosed and treated in Anyang Maternal and Child Health Care Hospital from July 2019 to May 2021 were selected as research objects. According to the patients' treatment intention, they were divided into surgery group (including 30 traditional surgery group and 30 combined surgery group), traditional Chinese medicine treatment group with 30 cases, and minimally invasive lavage treatment group with 30 cases. The efficacy and economy of each group were compared. Results The total cure rate of the surgery group was 81.6 %, including 90.0 % of the combined surgery group, 73.3 % of the traditional surgery group, 76.7 % of the traditional Chinese medicine group and 66.7 % of the minimally invasive lavage group. Comparison between the combined surgery group and other groups, and the differences were statistically significant (P < 0.05). The satisfaction degree of breast appearance in the combined surgery group was significantly higher than that in the other treatment groups (P < 0.05). The treatment time of the traditional Chinese medicine group was longer than that of the other treatment groups, and the average total treatment cost of the minimally invasive lavage treatment group was higher than that of the other treatment groups (P < 0.05). Conclusion After appropriate comprehensive treatment, non-lactating mastitis patients who choose surgery, traditional Chinese medicine, and minimally invasive lavage can achieve better efficacy. Surgical treatment can effectively reduce the risk of recurrence and improve the appearance of the breast, and is economical and optimal, especially the surgical treatment combined with mammaplasty.