〔Abstract〕 Objective To study the clinical effect of vaginal lactobacillus live capsule, Baiai lotion combined with Kushen membrane in the treatment of patients with mixed vaginitis. Methods A total of 60 patients with mixed vaginitis admitted to Jinjiang Hospital of Integrated Traditional Chinese and Western Medicine from January 2021 to February 2022 were randomly divided into an observation group and a control group with 30 cases in each group. The control group was treated with vaginal lactobacillus live capsule, and the observation group was treated with Baiai lotion and Kushen membrane on the basis of the control group. The total effective rate, incidence of adverse reactions, recurrence rate, and the levels of inflammatory factors in the recovery process of vaginal flora and results before and after treatment were compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group, and the incidence of adverse reactions and recurrence rate were lower than those of the control group, and the differences were statistically significant (P < 0.05). After treatment, the number of viable Lactobacillus in the observation group was higher than that in the control group, the number of viable enterobacter and yeast in the observation group was lower than that in the control group, and the serum levels of C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interleukin-8 (IL-8) were significantly lower than those in the control group, the differences were statistically significant (P < 0.05). Conclusion Patients with mixed vaginitis treated with vaginal lactobacillus live capsule and Bacitracin lotion combined with Kushen membrane can more effectively improve the clinical symptoms and inflammatory response, and the recurrence rate is low.