〔Abstract〕 Objective To analyze the therapeutic effect of Chaihu Shugan powder and Sijunzi decoction on epigastralgia pain. Methods 60 patients with epigastric pain who received treatment in Mingxi County Hospital of Traditional Chinese Medicine from March 2020 to March 2021 were selected and divided into two groups with 30 cases in each group by random number table method. The control group received conventional western medicine treatment, and the observation group received Chaihu Shugan powder combined with Sijunzi decoction. The therapeutic effect, improvement of traditional Chinese medicine (TCM) symptom scores, gastrointestinal hormone levels and other improvements as well as drug safety were compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P < 0.05). After treatment, the scores of belching and acid regurgitation, gastric pain and upper abdominal distension in the observation group were lower than those in the control group, the differences were statistically significant (P < 0.05). After treatment, the serum level of gastrin in the observation group was lower than that of the control group, while the levels of somatostatin and motilin were higher than those of the control group, the differences were statistically significant (P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P > 0.05). Conclusion Patients with epigastric pain were treated with Chaihu Shugan powder and Sijunzi decoction, and the TCM symptom scores were effectively improved, gastrointestinal hormone levels were effectively regulated, and no serious adverse reactions were caused during medication.