〔Abstract〕 Objective To observe the clinical effect of Yangjin decoction combined with sodium hyaluronate in the treatment of knee arthritis with liver and kidney deficiency. Methods 86 patients with primary knee arthritis admitted to Xinlicheng Angang General Hospital from June 2021 to June 2022 were selected and divided into a control group and an observation group by randomized control method, with 43 cases in each group. The control group was given sodium hyaluronate injection into the knee cavity, and the observation group was given Yangjin decoction on the basis of the control group. Patients' pain, severity and imaging changes before and after treatment were recorded, clinical efficacy was evaluated, and adverse reactions during treatment were recorded. Results After treatment, the visual analogue scale (VAS) score of the observation group was lower than that of the control group, and the difference was statistically significant (P < 0.05). After treatment, the score Western Ontario and McMaster University osteoarthritis index (WOMAC) in the observation group was lower than that in the control group, and the difference was statistically significant (P < 0.05). After treatment, Kellgren grading distribution in the observation group was better than that of the control group, and the difference was statistically significant (Z = -4.241, P < 0.05). The total effective rate of the observation group was 88.37 %, higher than 72.09 % of the control group, and the difference was statistically significant (P < 0.05). There were no obvious adverse reactions and no obvious abnormalities in liver and kidney function in the two groups during treatment. Conclusion Yangjin Decoction combined with sodium hyaluronate in the treatment of liver and kidney deficiency type knee arthritis has definite short-term effect and can effectively improve the condition.