〔Abstract〕 Objective To evaluate the effect of computed tomography angiography (CTA) on coronary artery stenosis in patients with non-ST-segment elevation myocardial infarction (NSTEMI). Methods Retrospective analysis was performed on 60 cases of NSTEMI patients admitted to People's Hospital Affiliated of Quanzhou Medical College from April 2018 to April 2020. All of them underwent CTA and coronary angiography (CAG) examination. The examination signs of CTA were statistically analyzed, and the coincidence rate of each coronary artery segment stenosis of CTA was evaluated compared with that of CAG. Kappa test was used to analyze the degree of coronary artery stenosis to assess consistency. Results 60 patients with NSTEMI were found to be associated with one or more signs after CTA examination. Among them, 49 cases of stenosis and occlusion, 43 cases of myocardial low-density area, 34 cases of local ventricular thickening, 20 cases of pleural effusion, 14 cases of pericardial effusion, 8 cases of myocardial calcification and 6 cases of ventricular aneurysm were detected. In a total of 420 coronary artery segments, 173 coronary artery segment stenosis was found by CAG examination, 159 coronary artery segment stenosis was found by CTA examination, the overall coincidence rate was 91.91 %, the left coronary artery (LM) was the highest, followed by left anterior descending (LAD), right coronary artery (RCA), and left circumflex artery (LCX). The accuracy rate of CTA was 80.00 % compared with that of CAG. The consistency Kappa test (κ = 0.700, P < 0.05) indicated that there was a high consistency between CTA and CAG. Conclusion The degree of coronary artery stenosis in NSTEMI patients can be evaluated by CTA, which has high diagnostic efficacy and is in good consistency with CAG. When severe stenosis of the main branch of the coronary artery or related important branches is detected,CAG examination can be further performed to avoid over-diagnosis.