多囊卵巢综合征孕妇并发妊娠高血压的危险因素分析
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(1.郑州大学第一附属医院,河南 郑州 450052)

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王磊,女,主治医师,主要研究方向是妊娠高血压方面。

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R 711.75;R 714.24+ 6

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Risk Factors of Pregnant Women with Polycystic Ovary Syndrome Complicated with Gestational Hypertension
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(1.The First Affiliated Hospital of Zhengzhou University, Henan Zhengzhou 450052)

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    摘要:

    摘 要目的:探讨多囊卵巢综合征(PCOS)孕妇并发妊娠高血压疾病(HDCP)的危险因素。方法:选择郑 州大学第一附属医院 2019 年 5 月至 2021 年 7 月收治的 148 例 PCOS 孕妇为研究对象,根据患者有无发生 HDCP 分 为 HDCP 组(78 例)和非 HDCP 组(70 例),根据文献资料及医生临床经验,筛选可能影响 PCOS 孕妇并发 HDCP 的相关因素,先后进行 logistic 单因素及多因素回归分析,判定影响 PCOS 孕妇并发 HDCP 的独立因素。结果:单因 素分析结果显示,HDCP 组孕妇孕前体质量指数(BMI)、高血压家族史、HDCP 家族、史被动吸烟史、孕前睾酮及 空腹胰岛素水平均高于非 HDCP 组,学历及家庭月收入低于非 HDCP 组,差异具有统计学意义(P < 0.05);多因 素 logistic 回归分析结果显示,孕前 BMI 高、高血压家族史、HDCP 家族史、孕前睾酮高水平及空腹胰岛素高水平均 是 PCOS 孕妇并发 HDCP 的危险因素,而学历高及家庭月收入高是 PCOS 孕妇并发 HDCP 的保护因素(P < 0.05)。结论:高血压家族史、HDCP 家族史均可能增加 PCOS 妊娠孕妇 HDCP 发病风险,孕期积极降低 BMI,行睾酮及胰 岛素监测,有助于降低 HDCP 发病风险。

    Abstract:

    AbstractObjective To explore the risk factors of hypertensive disorder complicating pregnancy (HDCP) in polycystic ovary syndrome (PCOS). Methods A total of 148 pregnant women with PCOS admitted to the First Affiliated Hospital of Zhengzhou University from May 2019 to July 2021 were selected as the study objects. According to whether the patients had HDCP or not, they were divided into HDCP group (78 cases) and non-HDCP group (70 cases). According to the literature and clinical experience of doctors, the factors that may affect the complication of HDCP in pregnant women with PCOS were selected. Logistic univariate and multivariate regression analysis were performed successively to determine the independent factors affecting HDCP in pregnant women with PCOS. Results Univariate analysis showed that pre-pregnancy body mass index (BMI), family history of hypertension, family history of HDCP, history of passive smoking, pre-pregnancy testosterone and fasting insulin levels in HDCP group were higher than those in non-HDCP group, education background and monthly family income were lower than those in non-HDCP group, and the differences were statistically significant (P < 0.05). Multivariate logistic regression analysis showed that high pre-pregnancy BMI, family history of hypertension, family history of HDCP, high pre-pregnancy testosterone level and high fasting insulin level were all risk factors for HDCP in pregnant women with PCOS, and high education and monthly family income were protective factors for HDCP in pregnant women with PCOS (P < 0.05). Conclusion Family history of blood pressure and HDCP may increase the risk of HDCP in pregnant women with PCOS. Active reduction of BMI and monitoring of testosterone and insulin during pregnancy can help reduce the risk of HDCP.

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  • 收稿日期:2022-10-23
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  • 在线发布日期: 2023-06-05
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