〔Abstract〕 Objective Taking the health care population in Shenzhen as the research object, the abnormal condition of physical examination was analyzed to provide corresponding countermeasures for further improving the health care management in Shenzhen. Methods A total of 31215 subject of physical examination in Shenzhen in 2021 were selected their blood pressure, blood glucose, blood lipid, uric acid and other data for grouping comparison and statistical analysis. Results The abnormal rates of blood pressure, blood glucose, blood lipid and uric acid in the health population were 18.81 %, 14.52 %, 19.67 % and 27.18 %, respectively. The four observation indicators in the health care population of different sex and age, and the differences were statistically significant (P < 0.001), the abnormal proportion of males was higher than that of females, and the abnormal blood lipid and uric acid were significantly higher in young, middle-aged and male. Conclusion We should pay attention to the health management of healthcare population, starting from the physical examination, adopt the way of health-care guidance and health education, and take the physical examination-intervention-prevention as the main line of service; In order to improve the health status of the population with abnormal physical examination, the intervention measures should be carried out in time, and the health management should be standardized according to the different gender and different age groups.