〔Abstract〕 Objective To investigate the effects of paper splint combined with wood splint fixation on wrist pain and comprehensive efficacy in patients with closed distal radius fractures. Methods A total of 108 patients with closed distal radius fractures admitted to Tongan District Hospital of Traditional Chinese Medicine of Xiamen from February 2020 to February 2021 were randomly divided into a control group and an observation group, with 54 cases in each group. The control group was treated with cast, and the observation group was treated with paper splint combined with wood splint. The comprehensive efficacy and clinical indicators of the two groups were compared. Results The total effective rate of the observation group was higher than that of the control group, the difference was statistically significant (P < 0.05). The wrist pain degree of the observation group was lower than that of the control group, and the fracture healing time was shorter than that of the control group, and the differences were statistically significant (P < 0.05). Conclusion Paper splint combined with wood splint fixation for patients with closed distal radius fractures can effectively reduce their wrist pain and promote recovery.