〔Abstract〕 Objective To explore the application effect of individualized cardiac rehabilitation education model in patients with acute myocardial infarction (AMI) percutaneous coronary intervention (PCI) perioperative period rehabilitation health education. Methods A total of 88 patients diagnosed with AMI and successfully underwent PCI in the First Affiliated Hospital of Nanyang Medical College from March 2019 to January 2020 were selected and divided into an observation group and a control group according to the random number table method, with 44 cases in each group. Patients in the control group were given routine in-hospital health education and out-of-hospital guidance, and patients in the observation group were given individualized cardiac rehabilitation education mode. The knowledge level of disease-related cardiac rehabilitation, exercise compliance and the effect of 6 min walking test on cardiac rehabilitation exercise before and after intervention were compared between the two groups. Results The disease knowledge, risk factors, exercise, social psychological risk and total score of the observation group were higher than those of the control group, and the differences were statistically significant (P < 0.05). The wechat step counting and wearing heart rate monitor in the observation group were higher than those in the control group, and the differences were statistically significant (P < 0.05). After the intervention, the 6 min walking distance of the observation group was longer than that of the control group, and the difference was statistically significant (P < 0.05). Conclusion The individualized cardiac rehabilitation education model can improve the cognition of cardiac rehabilitation in AMI patients during the perioperative period of PCI, improve aerobic exercise tolerance and rehabilitation exercise compliance.