〔Abstract〕 Objective To analyze the human papillomavirus (HPV) infection status of 18000 rural women in Pingtan area from January 2020 to March 2022, and to provide reference for cervical cancer screening, prevention and control of HPV infection and vaccine development. Methods The cervical cancer screening data of 18000 rural women whose primary screening method was HPV test in the Maternal and Child Health Hospital of Pingtan Comprehensive Experimental Area from January 2020 to March 2022 were retrospectively analyzed, and the test results were statistically analyzed. Results The detection rate of HPV infection was 12.02 % (2163/18000), the constituent ratio of high-risk HPV infection was 76.61 % (1657/2163), the constituent ratio of low-risk HPV infection was 23.39 % (506/2163), and the detection rate of single infection was 11.04 % (1987/18000). The detection rate of cervical precancerous lesions was 644.4/100 000 (116/18000), the detection rate of cervical cancer was 50/100 000 (9/18000), and the early diagnosis rate of cervical cancer was 96.69 % (117/121). There were 25 types of HPV genotyping detected, including 19 high-risk types, namely HPV16, 55, 52, 53, 18, 31, 33, 39, 56, 59, 66, 68, 51, 35, 45, 58, 82, 73 and 83. The top three were HPV16 (17.80 %), HPV55 (12.25 %) and HPV52 (8.46 %). There were 6 low-risk genotypes, namely HPV6, 11, 44, 43, 81 and 42, and HPV6 was the most common low-risk genotype (9.94 %). Conclusion There are geographical characteristics of HPV infection status and subtype distribution in cervical cancer screening women in Pingtan area. HPV detection as the primary screening method has guiding significance for cervical cancer screening strategy.