〔Abstract〕 Objective To investigate the effect of benazepril combined with bisoprolol on blood pressure and cardiac function in patients with hypertension and coronary heart disease. Methods A total of 80 patients with hypertension and coronary heart disease who were hospitalized in Nanyang First People's Hospital from January 2020 to August 2022 were selected and randomly divided into a control group and an observation group, with 40 cases in each group. The control group was treated with benazepril, and the observation group was treated with benazepril combined with bisoprolol. The blood pressure, hemorheology index, myocardial injury index, cardiac function index, and quality of life score were compared between the two groups before and after treatment. Results After treatment, compared with the control group, the systolic blood pressure, diastolic blood pressure, hemorheological indexes, myocardial injury indexes, N-terminal pro-B-type natriuretic peptide level and Tei index in the observation group were lower, while the left ventricular ejection fraction and quality of life score were higher, and the differences were statistically significant (P < 0.05). Conclusion Benazepril combined with bisoprolol is effective in the treatment of hypertension complicated with coronary heart disease, which can effectively control the blood pressure of patients, improve the hemorheology and cardiac function of patients, reduce myocardial injury, and improve the quality of life.