〔Abstract〕 Objective To analyze the application of hemodialysis safety belt combined with access management in blood purification of uremic patients. Methods The clinical data of 60 uremia patients who received blood purification treatment in Ninth People's Hospital of Zhengzhou from June 2019 to May 2022 were retrospectively analyzed. According to the safety protection and management measures of blood purification treatment, the patients were divided into the control group (routine tape fixation plus clinical intervention) and the observation group (hemodialysis safety belt plus clinical intervention plus access management), with 30 cases in each group. The fixed effect, comfort of dialysis treatment, treatment compliance and evaluation of intervention measures were compared between the two groups. Results In fixed efficiency, comfort of patients, score of compliance and evaluation of interventions of patients, the observation group had more advantages than the control group, the differences were statistically significant (P < 0.05). Conclusion When uremia patients receive blood purification treatment, routine clinical intervention combined with hemodialysis safety belt and access management can ensure the fixed effect, help to improve dialysis treatment, patients' comfort and compliance are ideal, and the recognition is high.