〔Abstract〕 Objective To investigate the efficacy and incidence of adverse events of stent thrombectomy in the treatment of acute ischemic stroke. Methods A total of 110 patients with acute ischemic stroke admitted to Nanyang Central Hospital from March 2021 to May 2022 were selected as the research objects. They were divided into the a control group and an observation group by computer randomization method, with 55 cases in each group. The control group was treated with intravenous thrombolysis, and the observation group was treated with stent thrombectomy. The vascular recanalization, neurological deficit, prognosis, and adverse events were compared between the two groups after treatment. Results The vascular recanalization rate and good prognosis rate in the observation group were higher than those in the control group, and the differences were statistically significant (P < 0.05). After treatment, the National Institutes of Health stroke scale (NIHSS) scores of the two groups were lower than those before treatment, and the NIHSS score of the observation group after treatment was lower than that of the control group, and the differences were statistically significant (P < 0.05). The incidence of adverse events in the observation group was 9.09 %, which was lower than 23.64 % in the control group, and the difference was statistically significant (P < 0.05). Conclusion Acute ischemic stroke patients were treated with stent thrombectomy, compared to intravenous thrombolysis scheme, it can improve the rate of vascular recanalization and good prognosis, improve the degree of neurological deficit, and reduce the incidence of adverse events.