〔Abstract〕 Objective To investigate the efficacy and postoperative complications of flat film tension-free hernioplasty in patients with inguinal hernia. Methods A total of 90 patients with inguinal hernia were treated in Fuqing Third Hospital from July 2020 to December 2021 were selected and divided into a control group and an observation group according to different treatment methods, with 45 cases in each group. The observation group received flat film tension-free hernioplasty, and the control group received traditional herniorrhaphy. The operation condition, postoperative recovery time, postoperative pain score, postoperative serum inflammatory factor index, postoperative complication rate, recurrence rate, preoperative and postoperative immune function index, and quality of life score were compared between the two groups. Results The operation time, postoperative exhaust recovery time, postoperative bed time and hospitalization time of the observation group were shorter than those of the control group, and the intraoperative blood loss was less than that of the control group, and the differences were statistically significant (P < 0.05). The postoperative pain scores of the observation group were lower than those of the control group, and the difference was statistically significant (P < 0.05). The levels of serum C-reactive protein and interleukin-6 in the observation group were lower than those in the control group, and the differences were statistically significant (P < 0.05). The incidence of complications and recurrence rate in the observation group were lower than those in the control group, and the differences were statistically significant (P < 0.05). The CD3+ and CD4+ /CD8+ in the observation group after surgery were higher than those in the control group, and the differences were statistically significant (P < 0.05). The quality of life scores of the observation group after surgery were higher than those of the control group, and the difference was statistically significant (P < 0.05). Conclusion Compared with traditional herniorrhaphy, flat film tensionfree hernioplasty for patients with inguinal hernia has the advantages of reducing intraoperative blood loss, alleviating postoperative pain, reducing postoperative complications, and accelerating postoperative rehabilitation. It can also reduce immune function damage of patients, reduce inflammatory factor exudation, reduce the recurrence rate, and improve the quality of life of patients.