〔Abstract〕 Objective To observe the clinical efficacy of self-made ditan tongqiao dingxuan decoction combined with acupuncture in the treatment of vertigo with phlegm stasis blocking orifice syndrome. Methods A total of 76 patients with vertigo with phlegm stasis blocking orifice syndrome were selected from Zhengzhou Traditional Chinese Medicine Orthopedics Hospital from September 2020 to October 2021. They were randomly divided into observation group and control group, with 38 cases in each group. The control group was treated with betahistine hydrochloride and sodium chloride injection, and the observation group was treated with ditan tongqiao dingxuan decoction plus acupuncture treatment. The scores of dizziness handicap inventory (DHI), duration of vertigo attacks, frequency of vertigo attack and cerebral hemodynamic indexes were observed in the two groups, and the clinical treatment effects were compared between the two groups.Results The total effective rate of patients in the observation group was 92.11 %, which was higher than 73.68 % in the control group (P ＜ 0.05). After treatment, the DHI score, duration of vertigo attack, and frequency of vertigo attacks in the two groups were significantly lower than those before treatment, and the DHI score, duration of vertigo attack and frequency of vertigo attack in the observation group were lower than those in the control group after treatment, the differences were statistically signficiant (P<0.05). The average blood flow velocity of basilar artery, left vertebral artery and right vertebral artery were higher than those before treatment, after treatment, the indexes of the observation group increased more significantly, the differences were statistically signficiant (P < 0.05). During the treatment, there was no adverse reactions in the two groups during treatment. Conclusion The self-made ditan tongqiao dingxuan decoction combined with acupuncture has a good effect on the treatment of vertigo with phlegm stasis blocking orifice syndrome. It can effectively relieve the symptoms of vertigo, shorten the duration of vertigo attacks, reduce the frequency of vertigo attacks, and improve cerebral hemodynamics.