〔Abstract〕 Infectious diseases seriously endanger human lives, health and social and economic development. Based on the comprehensive thinking of integrated traditional Chinese medicine and western medicine and profound understanding to cytokine networks, this article the author first proposed and established in the world: "identifying and distinguishing the cytokine storm feature of infectious diseases based on clinical manifestations of diseases", and the medical model of integrated Chinese and Western medicine, and proposed that coronavirus disease 2019 (COVID-19) was the result of cytokine storm resulted from the abnormal increase of biological activity of transforming growth factor-β (TGF-β) and other cytokines. This is an significant clinical medical achievement that can not be realized and achieved by only western medicine or traditional Chinese medicine, which fully demonstrates the progressiveness and scientific nature of integrated traditional Chinese medicine and western medicine.