〔Abstract〕 Objective To observe the effect of continuous veno venous hemofilration (CVVH) on blood norepinephrine concentration and clearance rate in patients with renal failure. Methods A total of 65 patients with renal failure admitted to the Second Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine from June 2020 to June 2021 were selected. All patients received CVVH treatment. The control group with 32 cases was treated with 2 L·h-1 displacement fluid, and the observation group with 33 cases was treated with 3 L·h-1 displacement fluid. The clinical indicators, blood norepinephrine concentration and clearance rate were compared between the two groups.Results The platelet count of the observation group was higher than that of the control group, and the Ca2+ concentration was lower than that of the control group, and the differences were statistically significant (P < 0.05). The clearance rate of norepinephrine in the observation group was higher than that in the control group, and the difference was statistically significant (P < 0.05). Conclusion For patients with renal failure, CVVH is effective, and the high displacement fluid flow rate has a higher clearance rate of norepinephrine, while the concentration of norepinephrine is not affected by the displacement fluid flow rate.