〔Abstract〕 Objective To study the effect of intradermal suture and interrupted suture on wound healing after spinal metastasis surgery. Methods A total of 85 patients with spinal metastases who needed surgery in Fujian Medical University Union Hospital from January 2020 to December 2021 were selected. 43 patients admitted from January, 2020 to December, 2020 were included in the control group, and they were sutured by interrupted suture. A total of 42 patients admitted to the hospital from January, 2021 to December, 2021 were included in the observation group and were sutured by intradermal suture. The incision suture time, dressing change times, healing time, incision complications, postoperative incision pain, and scar formation after healing were compared between the two groups. Results There was no significant difference in incision length between the two groups (P > 0.05). The suture time, the number of postoperative dressing changes, and the healing time of the observation group were less than those of the control group, and the Vancouver scar scale (VSS) score 1 month after the operation was lower than that of the control group, and the differences were statistically significant (P < 0.05). There was no statistically significant difference in the incidence of complications between the two groups (P > 0.05). The visual analogue scale (VAS) scores of the observation group on the first and second days after operation were lower than those of the control group, and the differences were statistically significant (P < 0.05). Conclusion Compared with interrupted suture, intradermal suture is more conducive to promoting incision healing, improving incision scar, and shortening the length of hospital stay of patients.