〔Abstract〕 Objective To compare the clinical indicators of hard channel and soft channel minimally invasive surgery in the treatment of hypertensive intracerebral hemorrhage (HICH). MethodsA total of 96 patients with HICH admitted to Sanmenxia Central Hospital from January 2020 to January 2022 were retrospective analysed their information. According to the treatment of 48 cases of patients treated with soft channel minimally invasive into soft channel group, the other from 48 cases of patients treated with hard channel minimally invasive into hard channel group, the preoperative and postoperative were compared between the two groups of patients.Results On the 7th day after operation, the serum stress response indexes of the two groups were lower than those before operation, and the serum stress response indexes of the soft channel group were lower than those of the hard channel group, and the differences were statistically significant (P < 0.05). 14 days after operation, the clinical indexes of the two groups were better than those before operation, the hematoma volume, perihematoma edema volume, and National Institutes of Health stroke scale (NIHSS) score in the soft channel group were lower than those in the hard channel group, and the activities of daily living (ADL) score was higher than that in the hard channel group (P < 0.05); The incidence of postoperative complications in the soft channel group was lower than that in the hard channel group, and the difference was statistically significant (P < 0.05). At 3 months after operation, the Glasgow outcome scale (GOS) grade of the soft channel group was better than that of the hard channel group, and the difference was statistically significant (Z = -2.863, P < 0.05). Conclusion Soft channel minimally invasive surgery in the treatment of HICH can reduce the postoperative stress response, reduce the incidence of postoperative complications, and improve the quality of prognosis.