〔Abstract〕 Objective To explore the clinical effect of local bone setting massage combined with oral Chinese medicine in the treatment of neck, shoulder, waist and leg pain. MethodsA total of 200 patients with neck, shoulder, low back and leg pain admitted to Zhangpu County Hospital from January 2019 to March 2022 were selected and divided into a control group and an observation group according to the random number table method, with 100 cases in each group. The patients in the control group were treated with local bone setting massage, and the patients in the observation group were treated with oral Chinese medicine on the basis of the control group. The clinical efficacy of the two groups were observed and compared.Results After treatment, the levels of tumor necrosis factor-α, C-reactive protein and interleukin-6 in the observation group were lower than those in the control group, and the differences were statistically significant (P < 0.05). After treatment, the visual analog scale (VAS) of the score of observation group was lower than that of the control group, and the scores of upper limb motor function, lower limb motor function and clinical assessment scale for cervical spondylosis (CASCS) were higher than those of the control group, with statistical significance (P < 0.05). The total efficacy rate of the two groups was 98.00 %, higher than 91.00 % of the control group, the differences were statistically significant (P < 0.05). After treatment, the traditional Chinese medicine (TCM) syndrome scores of the observation group were lower than those of the control group, and the differences were statistically significant (P < 0.05). ConclusionThe application of local bone setting massage in the treatment of patients with neck, shoulder, waist and leg pain, combined with the use of oral Chinese medicine treatment can significantly improve the overall efficacy, and effectively improve the clinical indicators.