〔Abstract〕 Objective To investigate the impact of project-oriented training assessment on central venous catheter complications in oncology chemotherapy patients. MethodsThe nurses were trained and assessed on the implementation of the central venous catheter maintenance project. A total of 744 cases of central venous catheterization in the internal medicine ward of Fujian Cancer Hospital from March 2019 to December 2019 were collected, and the catheter complications and indwelling time were analyzed to evaluate the training effect.Results In this study, unplanned extubation occurred in 36 cases (4.8 %), including 33 cases of catheter slippage and 3 cases of catheter-related bloodstream infection. No central venous catheter occlusion, thrombosis or catheter fracture occurred. No catheter-related complications occurred in 708 cases (95.2 %). The average catheter indwelling time was (19.18 ± 8.5) d, and the time span was 1-193 days. ConclusionProject-oriented training and assessment can improve the efficiency of clinical catheter maintenance and education, reduce the incidence of catheter complications, so as to prolong the catheter indwelling time and ensure the smooth progress of nursing.