〔Abstract〕 Objective To analyze the influencing factors of poor ulcer healing in patients with diabetic foot ulcer (DFU). MethodsA total of 108 patients with DFU admitted to the First Affiliated Hospital of Henan University of Science and Technology from January 2019 and November 2020 were selected as the research object, the patients were followed up for 6 months and according to the patients with ulcer healing situation were divided into poor healing group and good healing group, the baseline data and laboratory indexes were investigated and recorded, the influence factors of poor ulcer healing DFU patients were analyzed.Results After 6 months of follow-up, among 108 patients, 31 cases had poor ulcer healing, accounting for 28.70 % ; The proportion of the poor healing group with hypertension and no use of closed negative pressure drainage was higher than that of the good healing group, the level of glycated hemoglobin (HbA1c) at admission was higher than that of the good healing group, and the level of serum albumin (ALB) at admission was lower than that of the good healing group, with statistically significant differences (P < 0.05). Hypertension, no vacuum sealing drainage treatment, and high blood HbA1c level at admission were the risk factors for poor ulcer healing in the DFU patients (P < 0.05), and high serum ALB level at admission was a protective factor for ulcer healing in DFU patients (P < 0.05). Conclusion Combined hypertension, closed negative pressure drainage treatment, high blood HbA1c level and low serum ALB level at admission can increase the risk of poor ulcer healing in DFU patients. Clinical interventions should be formulated according to the above factors to promote ulcer healing and improve the prognosis of patients.