〔Abstract〕 Objective To analyze the effect of early mental nursing training on full term asphyxia neonates. Methods A total of 380 full-term asphyxia neonates treated from August 2019 to August 2021 were selected and divided into control group and observation group according to different nursing methods, with 190 cases in each group. The control group received routine nursing, while the observation group received routine nursing combined with early mental nursing training nursing. The nursing effects of the two groups were compared. Results The body length and body weight of the observation group at 3 and 6 months were higher than those of the control group, and the differences were statistically significant (P < 0.05). The neonatal behavioral nerve measurement (NBNA) scores of the observation group on the 14th and 28th days were higher than those of the control group, and the differences were statistically significant (P < 0.05). The scores of anxiety, depression and negative psychological state scores of the family numbers of the observation group on the 7th and 28th day were lower than those of the control group, and the positive score on the 28th day was higher than that in the control group, and the differences were statistically significant (P < 0.05). Conclusion Early mental nursing training for term asphyxia neonates can effectively promote the physical and behavioral neural development of the infants, and improve the psychological state of the families of the infants.