〔Abstract〕 Objective To observe the efficacy of endoscopic ligation in the treatment of esophageal and gastric varices bleeding (EGVB). Methods The data of 74 patients with EGVB treated by endoscopic ligation in Quanzhou City Emergency Command Center from June 2017 to December 2021 were retrospectively selected. Among them, 37 patients treated by endoscopic variceal ligation (EVL) alone were included in the control group. The other 37 patients who received EVL combined with endoscopic injection sclerosis (EIS) and tissue adhesives (TAI) injection were included in the observation group. The changes of pain degree within 72 hours after operation were compared between the two groups, and the occurrence of postoperative complications were statistically analyzed before discharge. The efficacy of the two groups was evaluated at 1 month after operation. Three months after operation, the indexes related to the operation effect of the two groups were observed: the number of varicose veins, the diameter of varicose veins, and the changes of portal vein blood flow. Results The postoperative pain score at 24 h, 48 h and 72 h of the observation group were lower than those of the control group. The clinical efficacy of the observation group was better than that of the control group. Three months after operation, the number of varicose veins, varicose vein diameter and portal blood flow in the observation group were lower than those in the control group, and the differences were statistically significant (P < 0.05). Conclusion Combining with EIS and TAI injection based on endoscopic ligation alone can further improve the clinical efficacy, and the surgical plan is safe and feasible