〔Abstract〕 Objective To understand the status of occupational exposure of medical staff in the Second Affiliated Hospital of Xiamen Medical College, so as to provide a basis for occupational safety protection of medical staff in the future. Methods The "Occupational Exposure Registration Form" was used to collect the basic information of occupational exposed personnel from 2019 to 2021, and SPSS statistical software was used to analyze the relevant data. Results A total of 281 people had occupational exposure in the Second Affiliated Hospital of Xiamen Medical College from January 1, 2019 to December 31, 2021, including 250 women (88.97 %). The average age was (26.46 ± 5.44) years old. Nursing staff accounted for the highest proportion (228 people, accounting for 81.14 %), followed by doctors (48 people, accounting for 17.08 %); Working years ≤ 3 years were prone to occupational exposure (149 people, accounting for 53.02 %); The occupational exposure in the third quarter of each year was relatively high (91 people, accounting for 32.38 %); The occupational exposure departments mainly occurred in emergency department, obstetrics department and operating room. The main type of occupational exposure was sharp instrument injury (needle) (234 people, accounting for 83.27 %), followed by mucosal exposure (31 people, accounting for 11.03 %). The main links of occupational exposure were treatment of medical waste (45 people, accounting for 16.01 %), treatment of materials (35 people, accounting for 12.46 %), separation of needles and syringes (32 people, accounting for 11.39 %), and surgical suture (23 people, accounting for 8.19 %). After occupational exposure, 267 people were reported in time, and the timely reporting rate was 95.01 %. 276 people could handle correctly after occupational exposure, and the correct disposal rate was 98.22 %. Conclusion Nurses with working years ≤ 3 years are the high-risk group of occupational exposure; The third quarter of each year is the time of high risk for occupational exposure; Medical waste disposal, sorting, needle and syringe separation, surgical suture and other operations are high-risk links of occupational exposure. Emergency department, obstetrics department and operating room are high-risk departments of occupational exposure. Good management of key population, key links and key departments can reduce the occurrence of occupational exposure of medical staff.