〔Abstract〕 Objective To study the efficacy of anti-pulmonary fibrosis traditional Chinese medicine (TCM) prescription in the treatment of pulmonary fibrosis (PF). Methods A total of 70 PF patients admitted to the Second Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine from March 2020 to October 2021 were selected and divided into a control group and an observation group by random number table method, with 35 cases in each group. Patients in the control group were treated with conventional western medicine, while patients in the observation group were treated with TCM anti-pulmonary fibrosis prescription on the basis of conventional western treatment. The clinical efficacy, TCM syndrome score, pulmonary function index, pulmonary fibrosis index, St. George's respiratory questionnaire (SGRQ) and high-resolution computed tomography (HRCT) score before and 3 months after treatment were compared between the two groups. Results The total effective rate of the observation group was 88.67 %, higher than 62.86 % of the control group, and the difference was statistically significant (P < 0.05). After treatment, the scores of fatigue, shortness of breath, perspiration and cough in the observation group were lower than those in the control group, and the differences were statistically significant (P < 0.05). After treatment, the forced expiratory volume in first second (FEV1), forced vital capacity (FVC) and peak expiratory flow (PEF) of the observation group were higher than those of the control group, and the differences were statistically significant (P < 0.05). After treatment, the levels of hyaluronic acid (HA), laminin (LN) and collagen type Ⅲ ( Ⅲ -Col) in the observation group were lower than those in the control group, and the differences were statistically significant (P < 0.05). After treatment, the SGRQ and HRCT scores of the observation group were lower than those of the control group, and the differences were statistically significant (P < 0.05). Conclusion The combination of TCM anti_x0002_pulmonary fibrosis prescription and conventional western medicine in the treatment of PF patients can further improve the clinical symptoms of patients, reduce the degree of pulmonary fibrosis, enhance pulmonary function, and improve the clinical efficacy. 〔Keywords〕 Pulmonary fibrosis; Anti-pulmonary fibrosis traditional Chinese medicine prescription; Prednisone acetate tablets; Pirfenidone capsules