〔Abstract〕 Objective To analyze the effect of whole course quality nursing in patients with alcoholic mental disorders. Methods A total of 64 patients with alcohol-toxic mental disorders who received treatment in Quanzhou Third Hospital from May 2021 to February 2022 were selected as the research objects. They were randomly divided into a control group and an observation group by drawing lots, with 32 cases in each group. The control group received basic nursing after admission, and the observation group received whole course high-quality nursing after admission. The nursing effect of the two groups was compared. Results After nursing, the excellent rate of treatment and nursing compliance in the observation group was higher than that in the control group, and the incidence of adverse events was lower than that in the control group. The scores of symptom self-rating scale (SCL-90), nursing delirium screening scale simplified Chinese version (Nu-DESC-SCV), Hamilton anxiety scale (HAMA), Hamilton depression scale (HAMD) and other mental state scores were lower than those in the control group, the differences were statistically significant (P < 0.05). Conclusion The implementation of whole-course high-quality nursing for patients with alcoholic toxic mental disorders can improve the treatment and nursing compliance of patients, reduce the risk of adverse events, promote the recovery of clinical symptoms and signs, improve delirium, anxiety, depression and other adverse psychology has positive significance.