〔Abstract〕 Objective To analyze the efficacy and prognosis of minimally invasive intervertebral foraminoscopic surgery for far lateral lumbar disc herniation (FLLDH). Methods A total of 50 patients with FLLDH admitted to Huadu District People's Hospital of Guangzhou from October 2019 to October 2021 were selected and divided into a control group and an observation group according to different surgical methods, with 25 cases in each group. The observation group was treated with minimally invasive foraminal endoscopic surgery, while the control group was treated with traditional surgery. The treatment effect and prognosis of the two groups were compared. Results The operation time and hospital stay of the observation group were shorter than those of the control group, and the amount of blood loss was less than that of the control group, and the differences were statistically significant (P < 0.05). After treatment, the visual analogue scale (VAS) and Oswestry disability index questionnaire (ODI) scores of the two groups were decreased compared with those before treatment, and the VAS and ODI scores of the observation group were lower than those of the control group, and the differences were statistically significant (P < 0.05). The complication rate of the observation group was 4.00%, lower than 24.00% of the control group, and the difference was statistically significant (P < 0.05). The excellent and good rate of the observation group was 96.00%, higher than 80.00% of the control group, and the difference was statistically significant (P < 0.05). Conclusion Minimally invasive intervertebral foraminoscopic surgery for FLLDH has good efficacy, which is conducive to improve the prognosis of patients and has high safety.