〔Abstract〕 Objective To study the value of shear wave elastography (SWE) in the diagnosis of Hashimoto's thyroiditis (HT) . Methods A total of 68 patients treated in Shenzhen Second People's Hospital from May 2019 to November 2021 were selected as the research objects, 41 patients with clinically diagnosed HT were selected as the observation group, and 27 patients with normal thyroid were selected as the control group. The mean value of thyroid elasticity (Mean) was measured by SWE and compared between the two groups. According to thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TgAb), and whether combined with thyroid dysfunction, the observation group was further divided into TPOAb extremely high group, elevated group, normal group, TgAb extremely high group, elevated group, normal group, normal thyroid function group, hyperthyroidism group and hypothyroidism group. The relationship between TPOAb, TgAb, thyroid function and Mean was analyzed. Results (1) Mean in the observation group was (27.59 ± 12.38) kPa and that in the control group was (11.96 ± 3.29) kPa. The thyroid tissue in the observation group was harder than that in the control group, and the difference was statistically significant (P < 0.05); (2) The results of receiver operating characteristic curve (ROC) analysis showed that the cut-off value for Mean diagnosis of HT was 19.5 kPa; (3) There was a significant positive correlation between TPOAb and Mean (r = 0.873, P < 0.05) below the upper limit of TPOAb of 1300 IU·mL-1, while there was no correlation between TGAb and Mean (P > 0.05) below the upper limit of TGAb of 500 IU·mL-1; There was no significant difference in Mean between normal thyroid function group, hyperthyroidism group and hypothyroidism group (P > 0.05). Conclusion It is helpful to diagnose HT by using SWE to measure Mean. Mean in HT patients is higher than that in normal patients, and it has a positive correlation with TPOAb below the upper limit of 1300 IU·mL-1. Thyroid function does not affect Mean.