〔Abstract〕 Objective To observe the clinical effect of Banxia Xiexin decoction combined with SOX regimen on patients with gastric cancer. Methods 80 patients with gastric cancer admitted to Shangqiu Hospital of Traditional Chinese Medicine from December 2018 to January 2021 were selected and divided into a control group and an observation group according to different treatment regimens, with 40 cases in each group. Patients in the control group were given SOX regimen chemotherapy, and patients in the observation group were given Banxia Xiexin decoction plus minus combined with SOX regimen chemotherapy. Chemotherapy completion rate, treatment effect, adverse reactions and quality of life of patients in the two groups were compared. Results The completion rate of the chemotherapy in the observation group was 92.50% (37/40), higher than 80.00 % (32/40) in the control group , and the difference was statistically significant (P < 0.05). The treatment effect of the observation group was better than that in the control group, and the difference was statistically significant (Z = 0.262, P < 0.05). The incidence of adverse reactions in the observation group was 8.10%, lower than 20.67% in control group, and the difference was statistically significant (P < 0.05). After treatment, the quality of life in the observation group was better than that in the control group, and the difference was statistically significant (Z = 0.262, P < 0.05). After treatment, the white blood cell count, hemoglobin content and platelet count in the two groups decreased to varying degrees, and the white blood cell count, hemoglobin content and platelet count in the observation group were higher than those in the control group after treatment, with statistical significances (P < 0.05). Conclusion Banxia Xiexin decoction combined with SOX chemotherapy has a definite effect on the treatment of gastric cancer, which has a significant effect on improving clinical symptoms, improving quality of life and reducing adverse reactions.