〔Abstract〕 Objective To investigate the clinical value of N-terminal B-type pronatriuretic peptide (NT-proBNP), hypersensitive C-reactive protein (hs-CRP) and homocysteine (Hcy) levels in predicting cardiovascular events in patients with chronic heart failure (CHF) at hospital discharge. Methods A total of 86 patients with CHF admitted to the 989th Hospital of the Joint Logistics Support Force from August 2018 to March 2020 were selected and followed up for 12 months after discharge. According to the incidence of cardiovascular adverse events during the follow-up period, all patients were divided into the cardiovascular event group with 45 cases and the non-cardiovascular event group with 41 cases. The levels of NT-proBNP, hs-CRP and Hcy were compared between the two groups, and the application value of each index in predicting cardiovascular events were analyzed by receiver operating characteristic curve (ROC). Results The levels of serum NT-proBNP, hs-CRP and Hcy in the cardiovascular event group were significantly higher than those in the non-cardiovascular event group, with statistical significances (P < 0.05). The levels of NT-proBNP, hs-CRP and Hcy of CHF patients at hospital discharge and their combined detection had the value of predicting short-term cardiovascular events in CHF patients. Conclusion The levels of NT-proBNP, hs-CRP and Hcy are closely related to cardiovascular events in patients with CHF, and can be used as indicators to predict the occurrence of cardiovascular events, and the combined detection of the three has high clinical application value.