〔Abstract〕 Objective To investigate the effect of stereotactic minimally invasive puncture and drainage on hematoma removal and neurological function recovery in patients with basal ganglia hemorrhage. Methods 70 patients with basal ganglia cerebral hemorrhage admitted to Xinzheng Tianyou Hospital of Traditional Chinese Medicine from January 2020 to June 2021 were randomly divided into an observation group and a control group with 35 cases in each group. The control group was treated with craniotomy hematoma removal, and the observation group was treated with stereotactic minimally invasive puncture catheter drainage. Perioperative indicators, postoperative hematoma clearance rate, neurological function before and after treatment, and incidence of postoperative complications were compared between the two groups. Results The operation time and hospitalization time of the observation group were shorter than those in the control group, and the amount of intraoperative blood loss was less than that in the control group, the differences were statistically significant (P < 0.05). There was no significant difference in hematoma clearance rate between the two groups (P > 0.05). The National Institutes of Health Stroke Scale (NIHSS) score in the observation group was lower than that in the control group, and the incidence of postoperative complications was 5.71 %, lower than 22.86 % in the control group, with statistical significances (P < 0.05). Conclusion Stereotactic minimally invasive puncture and drainage for the treatment of basal ganglia cerebral hemorrhage can shorten the operation time, reduce intraoperative blood loss, effectively remove intracranial hematoma, promote the recovery of neurological function, and then shorten the length of hospital stay, with high safety.