〔Abstract〕 The large extraperitoneal hematoma after cesarean section has a deep anatomical position and lacks specific clinical manifestations in the early stage. Fever is usually the first symptom, and in severe cases, disseminated intravascular coagulation may occur, which is life-threatening. The treatment is mainly surgical removal of hematoma, but the operation will bring secondary injury, infection, bleeding and a series of problems, aggravating maternal physical and psychological trauma. With the development of ultrasound interventional medicine, a new way of treating hematoma has been developed. Ultrasonic intervention combined with negative pressure suction can effectively remove large extraperitoneal hematoma after cesarean section, improve the symptoms of fever and abdominal pain caused by blood accumulation, and achieve precise minimally invasive surgery. The author retrospectively analyzed the data of 6 patients who were treated by ultrasonic intervention combined with negative pressure suction, summarized the technical experience, and hoped to provide reference for the clinical management of such patients.