〔Abstract〕 Objective To analyze the clinical effect of metoclopramide combined with granisetron in the treatment of acute alcohol toxicity induced vomiting. Methods 70 patients with acute alcohol poisoning induced vomiting admitted to the Affiliated Hospital of Putian University from January 2020 to January 2021 were randomly divided into a control group and an observation group, with 35 cases in each group. The control group was treated with metoclopramide, the observation group was treated with metoclopramide combined with granisetron. The anti-nausea efficacy, serum concentration of alcohol, systolic blood pressure, heart rate (HR), respiratory rate (RR) scale, mini-mental state examination (MMSE) score, the levels of serum 5-hydroxytryptamine (5-HT), β-endorphins (β-EP), dopamine (DA), norepinephrine (NE), nitric oxide (NO) and arginine vasopressin (AVP), alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyl transpeptidase (GGT) of patients were compared between the two groups. Results The total effective rate of the observation group was 94.29%, higher than 65.71% of the control group, and the difference was statistically significant (P < 0.05). After treatment, serum alcohol concentration in the two groups decreased to varying degrees, while systolic blood pressure, HR and RR increased to varying degrees. After treatment, serum alcohol concentration in the observation group was lower than that of the control group, while systolic blood pressure, HR and RR were higher than control group, the differences were statistically significant (P < 0.05). After treatment, the levels of 5-HT, NE, DA, NO, AVP and β-EP in the two groups were decreased to varying degrees, and the levels of 5-HT, NE, DA, NO, AVP and β-EP in the observation group were lower than those of the control group, the differences were statistically significant (P < 0.05). After treatment,the levels of AST, ALT and GGT in the two groups were decreased to varying degrees, and the levels of AST, ALT and GGT in the observation group were lower than those of the control group after treatment, the differences were statistically significant (P < 0.05). After treatment, MMSE scores in the two groups were improved to varying degrees, and MMSE scores in the observation group were higher than those of the control group, the differences were statistically significant (P < 0.05). ConclusionMetoclopramide combined with granisetron is effcetive in the treatment of acute alcohol poisoning induced vomiting, which can reduce alcohol concentration and neurotransmitter level.