〔Abstract〕 Objective To analyze the effect of atomization inhalation of acetylcysteine combined with vibration mechanical expectoration in the treatment of post-traumatic hypostatic pneumonia. Methods A total of 82 patients with pneumonia after traumatic brain injury admitted to the Second Affiliated Hospital of Henan University of Science and Technology from January 2020 to January 2021 were divided into a control group with 40 cases and an observation group with 42 cases according to different treatment methods. The control group was treated with vibrating mechanical expectoration, and the observation group was treated with aerosol inhalation of acetylcysteine on the basis of vibrating mechanical expectoration. The total effective rate, incidence of complications, levels of inflammatory factors before and after treatment and quality of life were compared between the two groups. Results The total effective rate in the observation group was 92.86%, which was higher than 75.00% in the control group, and the levels of IL-1β and TNF-α in the observation group were lower than those in the control group (P < 0.05). After treatment, the scores of physical function, psychological function and social function in the observation group were higher than those in the control group, the differences were statistically significant (P < 0.05). The incidence of complications in the observation group was 7.14%, which was higher than 5.00% in the control group, and there was no statistical significance between the two groups (P > 0.05). ConclusionAcetylcysteine atomization inhalation combined with vibration mechanical expectoration is effective in the treatment of hypostatic pneumonia after brain trauma, which can significantly reduce the inflammatory level, and improve quality of life, with a low incidence of complications.