〔Abstract〕 Objective To analyze the nursing effect of comprehensive nursing in lung lavage under fiberbronchoscope in the treatment of pulmonary infection in children. Methods A total of 72 children with pulmonary infection admitted to Panyu District Maternal and Child Health Care Hospital of Guangzhou from January 2020 to September 2021 were randomly divided into a control group and an observation group, with 36 cases in each group. The control group received routine nursing, and the observation group received comprehensive nursing. The oxygenation index, compliance, nursing satisfaction, quality of life, psychological status and complications of the two groups were compared. Results The compliance of the observation group was 97.22%, higher than 75.00% of the control group, the incidence of complications in the observation group was 2.78%, lower than 16.67% in the control group, the differences were statistically significant (P < 0.05); The oxygenation index of the observation group was higher than that of the control group, and the scores of self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were lower than those of the control group (P < 0.05); The total satisfaction of the observation group was higher than that of the control group, and the scores of physical function, mental intelligence and social function after nursing were higher than those of the control group, the differences were statistically significant (P < 0.05). Conclusion The application of comprehensive nursing has a good nursing effect in the treatment of pulmonary infection in children by bronchofibroscope lung lavage, which is helpful to improve the pulmonary function, with high safety, improve the quality of life of children, and promote the prognosis of the disease.