〔Abstract〕 Affected by factors such as young age, fever and discomfort, sensitivity to pain, and fear of the hospitals, children with corona virus disease 2019 (COVID-19) are prone to non-cooperation during treatment. It is not only difficult to achieve rapid relief of symptoms and pain, but also easy to lead to occupational exposure of medical staff. Therefore, reasonable nursing intervention should be carried out during the treatment of children with COVID-19, and standardized nosocomial infection prevention and control strategies should be adopted while improving the comfort level of children. Through literature review and focus group discussion, the author standardized environmental management, communication skills, nursing staff requirements, child identification, nursing operation, symptom care, life care, psychological care, health education, disinfection, isolation and occupational protection, occupational exposure emergency management, etc. This study provides a reference for the implementation of high-quality care for children with COVID-19