〔Abstract〕 Objective To evaluated the value of ultrasonic transient elastography (Fibroscan, FS) for hepatic fibrosis in patients with chronic hepatitis B. Methods A total of 80 patients with chronic hepatic B admitted to the First Affiliated Hospital of Henan University of Chinese Medicine from January 2018 to June 2020 were selected as the research subjects. All patients received hepatic biopsy and were divided into five groups according to the Results of needle biopsy. The patients were S0 group (24 cases), S1 group (21 cases), S2 group (15 cases), S3 group (9 cases) and S4 group (11 cases), and the liver stiffness measurement (LSM) value of all subjects was detected by FS. The LSM values of the five groups were compared. Spearman correlation analysis was conducted to analyze the correlation between LSM values and hepatic fibrosis stage, and receiver operating characteristic curve (ROC) was used to analyze the diagnostic value of LSM values for hepatic fibrosis degree. Results (1) LSM value increased with the increase of hepatic fibrosis stage (F = 128.98, P < 0.001). (2) Spearman correlation analysis showed that LSM value was highly positively correlated with pathological stage of liver fibrosis (R = 0.704, P < 0.001). (3) ROC curve analysis showed that the maximum cut-off value of the Youden index (0.551) was 6.76 kPa, the area under the curve was 0.850, the diagnostic sensitivity was 78.38%, and the specificity was 76.74% for patients with LSM diagnosis ≥ S1 stage. The maximum cut-off value of the Youden index (0.716) was 9.61 kPa, the area under the curve was 0.875, the diagnostic sensitivity was 88.24 %, the specificity was 83.33 % for patients with LSM diagnosis ≥ S2 stage. The maximum cut-off value of the Youden index (0.705) was 11.34 kPa, the area under the curve was 0.890, the diagnostic sensitivity was 90.48 %, and the specificity was 80.00 % for patients with LSM diagnosis ≥ S3 stage. The maximum cut_x0002_off value of the Youden index (0.755) for LSM diagnosis was 14.30 kPa, the area under the curve was 0.902, the diagnostic sensitivity was 84.62%, and the specificity was 90.91% for patients with LSM diagnosis S4 stage. Conclusion FS detection can accurately reflect the degree of hepatic fibrosis in patients with chronic hepatitis B.