〔Abstract〕 Objective To explore the clinical value of Liuwei Dihuang pill combined with metformin in the treatment of type 2 diabetes mellitus (T2DM) with Yin deficiency and internal heat syndrome. Methods A total of 120 T2DM patients admitted to Ruzhou Hospital of Traditional Chinese Medicine from January 2019 to March 2020 were selected as an observation group and a control group by random number method, with 60 cases in each group. Both groups were treated with metformin, while the observation group was treated with Liuwei Dihuang pill. The clinical effective rate, traditional Chinese medicine (TCM) syndrome score, blood glucose and lipid levels were compared between the two groups before and after treatment. Results The total clinical effective rate of the observation group was 93.33% after treatment, higher than 80.00 % of the control group, the difference was statistically significant (P < 0.05). Compared with before treatment, TCM syndrome score, fasting blood glucose (FPG) and 2h postprandial blood glucose (2h PG) levels in the two groups decreased after treatment, and the levels of the observation group were lower than those of the control group, the differences were statistically significant (P < 0.05). After treatment, the levels of low density lipoprotein (LDL), total cholesterol (TC) and triglyceride (TG) in the two groups were decreased, and the levels of the observation group were lower than those of the control group, the differences were statistically significant (P < 0.05). Conclusion Patients with T2DM treated with Liuwei Dihuang pill and metformin can effectively reduce the blood sugar and lipid levels, and significantly improve the patients' clinical symptoms.