〔Abstract〕 Objective To explore the effects of cognitive behavioral therapy (CBT) combined with refined nursing care on the sleep quality, mental state and coping styles of patients with chronic subjective tinnitus. Methods A total of 120 patients with chronic subjective tinnitus admitted to the First Affiliated Hospital of Zhengzhou University from June 2019 to February 2021 were selected and divided into a control group and an observation group by random number table method, with 60 cases in each group. The control group received routine nursing intervention, and the observation group received CBT and refined nursing intervention on the basis of the control group. The anxiety, depression and sleep quality of patients in the two groups were compared before and after intervention, the coping style of patients with disease was investigated, and the tinnitus disability degree of patients before and after intervention was assessed. Results After 2 months of intervention, the scores of self-rating anxiety scale (SAS), self-rating depression scale (SDS) and Pittsburgh sleep quality index (PSQI) scores in the observation group were lower than those in the control group, the differences were statistically significant (P < 0.05). After 2 months of intervention, the proportion of positive coping people in the observation group was higher than that in the control group, while the proportion of negative coping people was lower than that in the control group, the differences were statistically significant (P < 0.05). All dimensions scores and total scores of tinnitus handicap inventory (THI) in the observation group were lower than those in the control group after 2 months of intervention, and the differences were statistically significant (P < 0.05). Conclusion CBT combined with refined nursing for patients with chronic subjective tinnitus can effectively relieve their anxiety and depression, improve their sleep quality and tinnitus severity.