〔Abstract〕 Objective To analyze the effects of self-made traditional Chinese medicine prescription on postoperative fracture healing time and complications of proximal humeral fractures (PHF) in patients over 60 years old. Methods A total of 114 PHF patients over 60 years old. in Xiamen Tong 'an District Hospital of Traditional Chinese Medicine from March 2018 to August 2020 were selected and divided into a control group and an observation group, according to random number table method, with 57 cases in each group. The control group received minimally invasive surgery treatment, and the observation group received self-made traditional Chinese medicine prescription treatment on the basis of the control group, and the treatment effect of the two groups was compared. Results The excellent rate of operation in the observation group was higher than that in the control group, and the difference was statistically significant (P < 0.05). The fracture healing time of the observation group (50.14 ± 3.87) d was shorter than that of the control group (68.03 ± 5.27) d, and the difference was statistically significant (P < 0.05). The numerical rating scale (NRS) score of the observation group was lower than that of the control group at 3 d, 7 d and 14 d after surgery, the difference was statistically significant (P < 0.05). Constant-Murley shoulder function scores (CMS) in the observation group were higher than those in the control group at 1, 3 and 6 months after surgery, and the differences were statistically significant (P < 0.05). Three months after surgery, the levels of osteocalcin (OC) and bone alkaline phosphatase (BALP) in the observation group were higher than those in the control group, and the parathyroid hormone (PTH) and the special sequence of carboxy-terminal peptide β of type Ⅰ collagen (β-CTX) were lower than those in the control group, the differences were statistically significant (P < 0.05). The incidence of complications in the observation group was lower than that in the control group, and the difference was statistically significant (P < 0.05). Conclusion The self-made traditional Chinese medicine prescription for PHF patients over 60 years old can relieve the pain degree of patients, improve shoulder joint function, promote fracture healing, regulate the level of bone metabolic factors, improve the effect of surgical treatment, and fewer complications.