〔Abstract〕 Objective To observe the effect of Changyanning granules combined with compound eosinophil-lactobacillus tablets in children with rotavirus enteritis. Methods A total of 90 children with rotavirus enteritis treated in the First Affiliated Hospital of Henan University of Science and Technology from September 2019 to September 2021 were selected and divided into an observation group and a control group by random number table method, with 45 cases in ach group.The observation group (based on conventional treatment Changyanning granules combined with compound eosinophil-lactobacillus tablets treatment) and the control group (based on conventional treatment with compound eosinophil-lactobacillus tablets treatment), both groups were treated for 7 days. The curative effect of treatment for 7 days was compared between the two groups, and the symptom improvement condition and the levels of inflammatory factors [tumor necrosis factor (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP)] before and 7 days after treatment in the two groups were compared. Results The total effective rate in the observation group was 93.33% (42/45), higher than 77.78% (35/45) in the control group, and the difference was statistically significant (P < 0.05). After 7 days of treatment, the levels of TNF-α, CRP and IL-6 in the two groups were decreased to varying degrees, and the levels of TNF-α, CRP and IL-6 in the observation group were lower than those in the control group, the differences were statistically significant (P < 0.05). The time of antidiarrheal, antipyretic and antiemetic in the observation group was shorter than that in the control group, the differences were statistically significant (P < 0.05). Conclusion The combination of Changyanning granules and compound eosinophil_x0002_lactobacillus tablets can reduce the inflammatory response, relieve clinical symptoms and improve the efficacy in the treatment of rotavirus enteritis in children.