〔Abstract〕 Objective To analyze the effects of Huangqi Baoxin decoction combined with western medicine routine on cardiac function and readmission rate of patients with dilated cardiomyopathy complicated with chronic heart failure. Methods A total of 95 patients with dilated cardiomyopathy complicated with chronic heart failure in Xixian People's Hospital from September 2019 to August 2020 were selected and divided into a control group with 45 cases and an observation group with 50 cases according to difference treatment. The control group received conventional treatment of western medicine, and the observation group received Huangqi Baoxin decoction combined with conventional western medicine treatment. The efficacy, left ventricular ejection fraction (LVEF), 6 min walking distance, traditional Chinese medicine (TCM) syndrome score, serum aldosterone (ALD), angiotensin Ⅱ (AngⅡ), plasma renin activity (PRA) and readmission rate of the two groups were compared. Results The total effective rate in the observation group was 94.00%, higher than 73.33% in the control group, and the difference was statistically significant (P < 0.05). In terms of cardiac function, the walking distance 6 minutes after treatment in the observation group was longer than that in the control group, and the level of LVEF was higher than that in the control group, and the differences were statistically significant (P < 0.05). In terms of TCM syndrome score, the scores of shortness of breath, wheezing cough, palpitations, chest tightness, fatigue, exposure of green tendons and edema of lower limbs in the observation group were lower than those in the control group after treatment, with statistical significances (P < 0.05). After treatment, the levels of serum AngⅡ, PRA and ALD in the observation group were lower than those in the control group, the differences were statistically significant (P < 0.05). The readmission rate of the observation group [2.00 % (1/50)] was lower than that of the control group [15.56 % (7/45)], and the difference was statistically significant (P < 0.05). Conclusion Huangqi Baoxin decoction combined with conventional western medicine in the treatment of dilated cardiomyopathy complicated with chronic heart failure, the mechanism may be related to its inhibition of excessive activation of the renin angiotensin aldosterone system, protection of endothelial function, and inhibition of ventricular remodeling, which can significantly improve the patient's cardiac function and renin-angiotensin-aldosterone system, and reduce the readmission rate.