〔Abstract〕 Objective To explore the efficacy of acupoint application of traditional Chinese medicine (TCM) combined with intravenous rehydration in the treatment of pregnancy with disharmony between liver and stomach and its effect on the score of self_x0002_rating anxiety scale (SAS) and self-rating depression scale (SDS). Methods 80 cases of dysfunctional pregnancy with disharmony between liver and stomach treated in Quanzhou Hospital of Traditional Chinese Medicine from January 2019 to December 2021 were selected, they were randomly divided into two groups. Among them, 40 patients received intravenous rehydration treatment as the control group, and 40 patients received acupoint application of TCM combined with intravenous rehydration treatment as the observation group.The curative effect and recurrence of the two groups were compared, the food intake of the two groups after two days treatment were compared pregnancy–unique quantification of emesis and nausea (PUQE), SAS, SDS score, TCM clinical symptom score and urinary ketone body level were compared. Results The total effective rate of the observation group (95.00%) was higher than that of the control group (80.00%) (P < 0.05), and the recurrence rate (5.00%) was much lower than that of the control group (22.50%) (P < 0.05). Two days after treatment, the food intake of the observation group was significantly higher than that of the control group (P < 0.05). After treatment, the urinary ketone body and clinical symptom scores of the two groups were lower than those before treatment, and the urinary ketone body and clinical symptom scores of the observation group were lower than those of the control group after treatment, the differences were statistically significant (P < 0.05). After treatment, the PUQE, SAS and SDS scores of the two groups were lower than those before treatment, and the PUQE, SAS and SDS scores of the observation group were lower than those of the control group, the differences were statistically significant (P < 0.05). Conclusion Acupoint application of traditional Chinese medicine combined with intravenous rehydration can effectively reduce the clinical symptoms of liver stomach disharmony and malignant obstruction of pregnancy, alleviate patients' anxiety and depression state.