〔Abstract〕 Objective To investigate the application and effect of different bedside elevation angles in patients with mechanical ventilation in ICU. Methods A total of 200 patients admitted to ICU of the Third People's Hospital of Hechi City from January 2015 to December 2019 were selected as the research objects, and they were divided into a control group and an observation group according to random number table method, with 100 patients in each group. In the observation group, the head of the bed was continuously raised 20° ~ 25°, and the head of the bed was raised 30° ~ 45° after nasogastric feeding and 2 h after nasogastric feeding. The control group continued to elevate the head of the bed by 30° ~ 45°.The incidence of aspiration, ventilator-associated pneumonia (VAP) and pressure ulcers were compared between the two groups. Arterial partial pressure of oxygen (PaO2) and arterial partial pressure of carbon dioxide (PaCO2) were monitored. Results There was no significant difference in the incidence of wrong inhalation and VAP between the observation group and control group (P > 0.05). The incidence of pressure ulcers in the observation group was significantly lower than that in the control group, the difference was statistically significant (P < 0.05). There was no significant difference in PaO2 and PaCO2 levels between the two groups before and after treatment (P > 0.05). Conclusion For patients with mechanical ventilation in ICU, raising the head of bed continuously at 20° ~ 25° can effectively prevent pressure ulcers and does not increase the risk of VAP, so it is an ideal position.